Mike Myers

Simon Jones has appeared in the films Miracle on 34th Street, For Love or Money, Green Card, Brazil, and Monty Python's Meaning of Life, among others. He has beer featured on Broadway in The Real Thing, Benefactors, and Private Lives.

From the sixties spy Austin Powers and his nemesis Dr. Evil, to metalhead Wayne, and the German pseudo-intellectual Dieter, Mike Myers has created some of the biggest characters in popular culture. While Myers is a huge movie star, his rise to fame is not well known. Best-selling biographer Martin Knelman chronicles Myers' early career from the first television appearance of Wayne's World (not on Saturday Night Live), to his breakthrough success on Saturday Night Live and movies such as Wayne's World and Austin Powers.

The road to success has not always been smooth. His first hit movies were followed by flops. Portraits of Myers as a vain control freak began to surface in the media including a vicious profile in Vanity Fair. Accusations intensified when Myers, facing a multi-million dollar lawsuit and intense criticism from the Hollywood establishment, stopped production on a movie based on his Dieter character because it wasn't funny enough. Only with the intervention of Jeffrey Katzenberg did Mike Myers' career and reputation bounce back with the overwhelming success of Shrek.

Mike's World explores the controversies and successes of Myers' career. This compelling portrait of a passionate artist who is devoted to his career, his family and wife. It is above all about a man who continues to live by his late father's advice: always be funny.

The biological interactions of living organisms, and protein-protein interactions in particular, are astonishingly diverse and present numerous challenges to modern biomolecular research because of their complexity. Analysis of patterns and principles governing these interactions has prompted a rapid development of computational methods to identify protein interaction partners and to understand the roles of individual components of protein interaction networks in cell functions.

This book integrates different approaches from bioinformatics, biochemistry, computational analysis and systems biology to offer the reader a comprehensive global view of the diverse data on protein-protein interactions and protein interaction networks. It brings together the descriptions of experimental techniques and expounds on different computational algorithms for protein network analysis and prediction of protein and domain interactions, with each chapter containing a description of the problem, a review of methods and algorithms, a list of resources and current conclusions.

Features

• Reviews experimental techniques for identification of protein interactions

• Discusses protein interaction databases and methods of integrating data from diverse sources

• Describes computational methods to predict protein and domain interaction partners

• Explores the properties of interaction interfaces and highlights approaches to model the assembly of protein complexes

• Examines the topological and dynamical properties of protein interaction networks and presents the tools for comparative analysis of these networks

Written by leading experts, Protein-protein Interactions and Networks provides a broad, thorough and multidisciplinary coverage of this field. It will be invaluable to researchers from academia and the bioinformatics industry, as well as an excellent auxiliary text for graduate students studying the topic.